Neurol Med Chir (Tokyo) 52(7):470–474īabu R, Hazzard MA, Huang KT, Ugiliweneza B, Patil CG, Boakye M, Lad SP (2013) Outcomes of percutaneous and paddle lead implantation for spinal cord stimulation: a comparative analysis of complications, reoperation rates, and health-care costs. However, evidence is limited and long-term prospective studies will be required to identify the optimal candidates for SCS and the best parameters of stimulation and to fully characterize the effects of stimulation on motor and nonmotor symptoms of PD.Īgari T, Date I (2012) Spinal cord stimulation for the treatment of abnormal posture and gait disorder in patients with Parkinson’s disease. SCS appears to yield positive results for PD symptoms, especially for impairments in gait function and postural stability. The overall motor score of the Unified Parkinson’s Disease Rating Scale in the on/off-stimulation condition remained unchanged in 6 patients and improved in 18 patients after SCS. Eight studies with a total of 24 patients were included in this review. Reports examining SCS for the treatment of PD are limited. The methodology utilized in this work follows a review process derived from evidence-based systematic review and meta-analysis of randomized trials described in the PRISMA statement. A comprehensive literature search was conducted using electronic databases for the period from January 1966 through April 2014. Our purpose was to systematically review the effectiveness of SCS for the treatment of motor symptoms of PD and to evaluate the technical and pathophysiological mechanisms that may influence the outcome efficacy of SCS. Spinal cord stimulation (SCS) may be a new therapeutic approach for the alleviation of levodopa-resistant motor symptoms of PD. Axial symptoms are a late-developing phenomenon in the course of Parkinson’s disease (PD) and represent a therapeutic challenge given their poor response to levodopa therapy and deep brain stimulation.
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